Final answer:
RNA polymerase III cannot synthesize over lesions because it cannot catalyze the formation of peptide bonds between tRNAs in the A and P sites.
Step-by-step explanation:
Pol III, also known as RNA polymerase III, cannot synthesize RNA over lesions because it is unable to catalyze the formation of peptide bonds between the transfer RNAs (tRNAs) in the A and P sites.