Final answer:
The Vulgate translation was the first to use italics in English to indicate words not directly translated from the original.
Step-by-step explanation:
The Vulgate translation was the first to use italics to indicate words in English that were not directly translated from the original. The Vulgate, produced by Jerome in 410, was a Latin version of the Christian Bible that became the main edition in Europe until the sixteenth century. This translation introduced the use of italics to emphasize certain words or phrases.