70.6k views
5 votes
A patient presents w/ fatigue, petechiae, infection bone pain and HSM...

Tartate resistant acid phosphatase, ↓monos & CD11 and CD22+?

User Zeratool
by
7.5k points

1 Answer

4 votes

Final answer:

A patient with symptoms and lab findings such as fatigue, petechiae, infection, bone pain, HSM, tartate resistant acid phosphatase, low monocytes, and CD11 and CD22 positivity could be indicative of a hematologic condition like leukemia or lymphoma. A thorough diagnostic work-up is necessary for accurate diagnosis and appropriate treatment. Considering the differential diagnosis for these findings may include infections or other blood diseases.

Step-by-step explanation:

The patient presenting with symptoms such as fatigue, petechiae, bone pain, infection, and hepatosplenomegaly (HSM), along with lab findings including tartate resistant acid phosphatase and low monocytes, with CD11 and CD22 positivity is suggestive of a hematologic condition. Although the clinical scenario does not provide a definitive diagnosis, the mentioned findings could be associated with various blood disorders or malignancies. A clinician might consider conditions such as acute leukemia, and further diagnostic work-up with complete blood count, additional immunophenotyping, and possibly a bone marrow biopsy would be indicated to clarify the diagnosis.

The reference to tartate resistant acid phosphatase is typically associated with hairy cell leukemia, but other conditions could also present similarly. The fact that CD22 is positive indicates a B-cell lineage, which is associated with B-cell leukemias or lymphomas. A decrease in monocytes could suggest a possible bone marrow involvement or suppression.

These lab findings and symptoms require careful differential diagnosis, which may include entities such as infectious mononucleosis, Ehrlichia chaffeensis infection (associated with ehrlichiosis), and bacterial infections like rat-bite fever caused by Streptobacillus moniliformis. Differentiating these conditions is critical, as they may have distinct treatments ranging from antimicrobial therapy to more aggressive treatments like chemoimmunotherapy depending on the final diagnosis.

User Alexander Oprisnik
by
8.3k points