Final answer:
Type I Renal Tubular Acidosis (RTA) is caused by impaired acid excretion in the kidneys. It can be diagnosed through blood and urine tests and is treated with alkalizing agents.
Step-by-step explanation:
Type I Renal Tubular Acidosis (RTA) is caused by an impaired ability of the kidneys to excrete hydrogen ions. This leads to a buildup of acid in the blood and a decrease in bicarbonate levels. Common causes of Type I RTA include autoimmune diseases, such as Sjogren syndrome and systemic lupus erythematosus, as well as certain medications like amphotericin B.
Individuals with Type I RTA may present with symptoms such as fatigue, muscle weakness, and urinary symptoms like polyuria. Diagnosis is made through blood tests that show low bicarbonate levels and urine tests that confirm impaired acid excretion. Treatment usually involves the administration of alkalizing agents like sodium bicarbonate to correct the acid-base imbalance.