Final answer:
The most important route of elimination for most antimicrobial agents is through the kidneys, with urine excretion being the primary method. The liver may also play a role in metabolizing and eliminating some antimicrobials through bile.
Step-by-step explanation:
The most important route of elimination of most antimicrobial agents is through the kidneys, specifically via urine excretion. Antimicrobials are often designed to be efficiently filtered out of the bloodstream by the kidneys and then excreted in urine, removing the active compound and its metabolites from the body. The liver also plays a significant role in drug metabolism and can be a secondary route of elimination for some antimicrobials through bile excretion. However, the kidneys are typically the primary organ for clearing antimicrobials from the system due to their pivotal role in filtering blood and removing waste products.