Impaired ventricular diastolic filling can result in decreased stroke volume and cardiac output, crucial components of heart function affected by disruptions in the cardiac cycle's phases.
Impairment of ventricular diastolic filling can be caused by increased pericardial sac pressure or abnormal bulging of the ventricular septum into the left ventricle (LV). During the cardiac cycle, ventricular systole is followed by ventricular diastole, where the ventricles relax and fill with blood. If these phases are disrupted, stroke volume and cardiac output may decline.
This can have significant implications for heart function, as stroke volume, typically ranging from 70-80 mL, represents the amount of blood pumped by each ventricle with each heartbeat. The remaining volume, after the heart contracts, is the end-systolic volume (ESV). During diastole, normal filling of the ventricles is crucial for maintaining adequate cardiac output and circulation.
In conclusion, proper functioning of the cardiac cycle is essential for maintaining cardiovascular health and preventing conditions that may impair ventricular filling, which in turn can lead to reduced cardiac output and stroke volume.