Question

Which Azole is water insoluble, well absorbed from the GI tract & less affected by high pH, less potent as an inhibitor of steroid synthesis, & widely distributed in tissues, saliva, & CSF?

Answer 1

The azole described is likely a triazole antifungal such as fluconazole, known for its good GI absorption, less potency as a steroid synthesis inhibitor, wide tissue distribution, and fewer side effects compared to imidazoles.

Step-by-step explanation:

The Azole you are asking about, which is water-insoluble, well absorbed from the GI tract, and less affected by high pH, is likely an azole antifungal agent. This type of drug is less potent as an inhibitor of steroid synthesis and demonstrates a high degree of tissue penetration, including distribution in tissues, saliva, and CSF (cerebrospinal fluid). Among the azole antifungals, the triazoles are known for these characteristics. They have the added benefit of being oral or intravenous options for treating several types of systemic yeast infections with more selective toxicity and fewer side effects than imidazoles. Fluconazole, in particular, might be the azole described in your question, as it is known for good oral absorption and wide distribution in body fluids and tissues.