Final answer:
Alternative routes have emerged for drug delivery in PALS, including controlled-release parental drug, mucosal route, oral route, and transdermal route. Intravenous or intramuscular injection is preferred when a drug is not absorbed in the GI tract, as it results in higher plasma levels compared to other administration routes.
Step-by-step explanation:
Priorities for drug delivery routes in PALS
In the administration of peptide-based drugs, alternative routes have emerged to improve drug delivery. Some of these routes include controlled-release parental drug, mucosal route, oral route, and transdermal route. In certain situations where a drug is not absorbed in the gastrointestinal (GI) tract, parenteral routes like intravenous or intramuscular injection are preferred as they result in higher plasma levels compared to oral or intramuscular administration. This consideration is important when choosing the route of administration for treating infections.