Final answer:
The most common route of administration for nitroglycerin is sublingual.
Step-by-step explanation:
Nitroglycerin is used to relieve chest pain in heart disease, and the sublingual route of administration allows for rapid absorption and quick onset of action.
Intravenous (IV), intradermal, and suppository routes are not commonly used for nitroglycerin administration.
This method is particularly effective for the rapid relief of chest pain associated with heart disease because it allows for quick absorption into the bloodstream. Immediate treatments for myocardial infarction (MI) often include the sublingual administration of nitroglycerin to aid in the absorption and rapid initiation of its vasodilative effects. Nitroglycerin works, in part, by releasing nitric oxide, a vasodilator that helps relax the smooth muscles in coronary vessels, improving blood flow and reducing the heart's workload.