Final answer:
The MOA of bismuth subsalicylate involves its antimicrobial properties and protective coating, while sucralfate forms a protective barrier and stimulates healing.
Step-by-step explanation:
The MOA (mechanism of action) of bismuth subsalicylate, commonly known as Pepto-Bismol, is multifactorial. It has antimicrobial properties that help combat bacterial infections in the stomach, including Helicobacter pylori. It also forms a protective coating on the surface of the stomach and intestines, acting as a barrier against gastric acid and irritating substances.
Sucralfate, on the other hand, works by adhering to the gastric ulcers or erosions, forming a protective barrier. This barrier prevents gastric acid, digestive enzymes, and bile salts from further damaging the mucosa, allowing the ulcer to heal. Additionally, sucralfate stimulates the production of prostaglandin, a protective substance that promotes the secretion of bicarbonate and mucin to enhance the healing process.