Final answer:
GGT elevation is most often associated with liver diseases, especially related to alcohol toxicity. It is used to ascertain the cause of isolated ALP elevation and can indicate various liver dysfunctions including acute liver damage and genetic disorders like Gilbert's syndrome.
Step-by-step explanation:
Elevation of gamma glutamyl transpeptidase (GGT) is most commonly associated with liver diseases, particularly due to alcohol toxicity. GGT is a sensitive marker for liver damage and cholestatic injury, and it often increases with liver dysfunction which can range from minor to severe. The elevation of GGT helps in differentiating the cause of isolated increases in ALP (alkaline phosphatase), another enzyme associated with liver and bone diseases. Moreover, while GGT elevations are particularly notable in liver disorders, it's important to recognize that other clinical situations, such as acute liver damage, obstructions like Budd-Chiari syndrome, Gilbert's syndrome, and different forms of hepatitis could also result in an increased GGT level.