Final answer:
For an exchange transfusion related to HDFN due to anti-D and ABO incompatibility, the donor red blood cells should be both leukoreduced to minimize immune reactions and washed to remove residual plasma proteins and antibodies.
Step-by-step explanation:
The most appropriate criteria for donor red blood cells (RBCs) for an exchange transfusion related to both Hemolytic Disease of the Newborn (HDFN) due to anti-D and ABO HDFN are leukoreduced and washed RBCs.
Leukoreduced blood products have been filtered to remove the white blood cells, or leukocytes. This is done to minimize the risk of febrile non-hemolytic transfusion reactions and reduce the transmission of leukocyte-associated viruses. In the case of HDFN, leukoreduced RBCs could help prevent possible immune reactions from the mother's immune system against the donor leukocytes.
Washed RBCs have been processed to remove most of the plasma, which contains antibodies and proteins. This is particularly important for patients who have allergic reactions to plasma proteins or are at risk for HDFN, where any residual antibodies in the donor blood might exacerbate the condition.
Irradiated RBCs are used to prevent transfusion-associated graft-versus-host disease (TA-GVHD), which is not typically associated with HDFN. Freshly thawed blood refers to frozen RBCs that have been thawed for transfusion and is not a specific requirement for HDFN-related transfusions.