Final answer:
Options A and B use correct punctuation for a quotation.
Step-by-step explanation:
The correct punctuation for a quotation is:
A. "A good laugh and a long run," she said. "Are the two best cures for anything."
Option B also uses correct punctuation: "A good laugh and a long run," she said, "are the two best cures for anything."
Options C and D do not use correct punctuation because the comma after the quotation should be inside the quotation marks.