Final answer:
Sickle cell anemia is the condition most associated with autosplenectomy.
Step-by-step explanation:
Sickle cell anemia is the condition most associated with autosplenectomy. Autosplenectomy refers to the gradual destruction of the spleen in individuals with certain medical conditions.
In sickle cell anemia, the red blood cells become sickle-shaped and can get trapped in small blood vessels, leading to reduced blood flow and damage to organs including the spleen. Over time, this can cause the spleen to shrink and ultimately be non-functional, a condition known as autosplenectomy.
Iron deficiency, abdominal trauma, and thrombocytopenia are not typically associated with autosplenectomy.