Final answer:
Amitriptyline, doxepine, nortriptyline, and amoxapine inhibit the reuptake of neurotransmitters in the brain, specifically norepinephrine and serotonin. They also have anticholinergic and sedative properties.
Step-by-step explanation:
The MOA (Mechanism of Action) of amitriptyline, doxepine, nortriptyline, and amoxapine is that they inhibit the reuptake of neurotransmitters, specifically norepinephrine and serotonin, in the brain. This leads to increased levels of these neurotransmitters in the synaptic cleft, which can help alleviate symptoms of depression. Additionally, these medications have anticholinergic and sedative properties.