Question

For intramembranous ossification to take place, which of the following is necessary?

a. the cartilage matrix begins to deteriorate
b. a medullary cavity forms
c. ossification centers form in the fibrous connective tissue membrane
d. a bone collar forms around the cartilage mode

Answer 1

Intramembranous ossification begins when mesenchymal cells form ossification centers in the fibrous connective tissue membrane. Osteoblasts differentiate and secrete the extracellular matrix, leading to the formation of spongy bone. Compact bone then develops, and blood vessels condense into red marrow.

Step-by-step explanation:

Intramembranous ossification is the process of bone development from fibrous membranes. It begins with mesenchymal cells grouping into clusters and forming ossification centers in the fibrous connective tissue membrane. Osteoblasts, which secrete the extracellular matrix and deposit calcium, then differentiate and become osteocytes. The matrix continues to form around blood vessels, leading to the formation of spongy bone. Finally, compact bone develops superficially, and blood vessels condense into red marrow.