Question

Does hyperlipidemia Type III lead to hypercholesterolemia? Is this disease common or rare? Which lipoprotein is increased in plasma and contains cholesteryl esters? Which apoprotein is less functional?

a) Yes; Common; LDL; Apo B-100
b) No; Rare; HDL; Apo A-I
c) Yes; Rare; VLDL; Apo C-II
d) No; Common; IDL; Apo E

Answer 1

Hyperlipidemia Type III, or dysbetalipoproteinemia, leads to an increase in VLDL levels containing cholesteryl esters due to a less functional Apo E protein. It is a rare condition, with a prevalence of 0.02%.

Step-by-step explanation:

Hyperlipidemia Type III, also known as dysbetalipoproteinemia, is characterized by the presence of elevated levels of chylomicrons and intermediate density lipoprotein (IDL) in the plasma. This condition is associated with the ApoE E2/E2 genotype, which results in cholesterol-rich very low density lipoprotein (VLDL). The prevalence of this condition is about 0.02% of the population, which makes it relatively rare. In this disease state, the lipoprotein that is increased in plasma and primarily contains cholesteryl esters is VLDL. Apolipoprotein E (Apo E) is the apoprotein that is less functional in hyperlipidemia Type III. Therefore, the correct answer to the student's question is c) Yes; Rare; VLDL; Apo E.