Final answer:
The advantages of applying a biosynthetic skin substitute for full-thickness burns include reduced risk of infection, decreased loss of plasma protein and fluid, and more rapid healing. They do not, however, result in stronger fibrous scar tissue or the regeneration of all glands, nerves, and hair follicles.
Step-by-step explanation:
The question pertains to the advantages of applying a biosynthetic skin substitute to a large area of full-thickness burns. Such substitutes may reduce the risk of infection due to the protective layer they provide, which acts as a barrier to pathogens. Moreover, they can decrease the loss of plasma protein and fluid by serving as a temporary closure of the wound and providing a matrix for tissue ingrowth, which leads to more rapid healing.
However, they generally do not lead to the regeneration of all glands, nerves, and hair follicles, nor do they result in stronger fibrous scar tissue compared to the body's natural healing process, which can leave scars comprised largely of collagen. Therefore, the correct answer to the advantages of using a biosynthetic skin substitute for full-thickness burns would be options 1, reduced risk of infection, 2, decreased loss of plasma protein and fluid, and 4, more rapid healing, which corresponds to choice c.