Final answer:
Granulation tissue forms as part of the healing process but is replaced by scar tissue, which differs from the original tissue and is not a permanent replacement. Therefore, the correct statement is that scar tissue forms where the surrounding cells are incapable of mitosis and granulation tissue is not permanent.
Step-by-step explanation:
The correct answer to the statement regarding wound healing is that granulation tissue does not form a permanent replacement for damaged tissue. This is because granulation tissue initially forms as part of the healing process to fill the wound and promote the formation of new blood capillaries. Eventually, granulation tissue is replaced by scar tissue, particularly when the surrounding cells are not capable of mitosis. Scar tissue is made up mainly of collagen produced by fibroblasts and lacks the original structures of the tissue, such as hair follicles or sweat glands.
During the wound healing process, a blood clot halts blood flow and a scab forms. Fibroblasts create a matrix of collagen, which plays a role in forming granulation tissue, and over time, a scar. The regenerated tissue is unable to fully restore all original cell types and structures, resulting in a scar that functions differently from the original tissue. In large wounds, sutures may be used to promote primary union and minimize scarring.