Final answer:
Malaise and anorexia are systemic symptoms of inflammation, but they are not considered cardinal signs which describe local changes like redness, swelling, heat, pain, and altered function due to inflammation.
Step-by-step explanation:
The systemic manifestations of inflammation that are generally observed include symptoms such as malaise, which is a feeling of general discomfort or uneasiness, and anorexia, which is a lack or loss of appetite for food. However, when discussing which of these is not a cardinal sign of inflammation, it's important to differentiate between local and systemic signs. The five cardinal signs of inflammation are erythema (redness), edema (swelling), heat, pain, and altered function.
These signs are mainly due to the immediate response of the innate immune system to an infection or injury, with increased blood flow and various cellular and chemical responses in the affected tissue. While systemic effects such as fever can accompany inflammation, it must be noted that malaise and anorexia are indeed systemic symptoms, but they are not considered cardinal signs, which specifically describe the local physiological changes that directly result from the inflammatory response.