Question

Which two apoproteins are needed for the release of lipoproteins and are also needed for uptake into respective cells and are never interchanged with other lipoproteins?

a) Apo A-I and Apo B-100
b) Apo B-48 and Apo C-II
c) Apo E and Apo A-I
d) Apo B-100 and Apo E

Answer 1

Apo B-100 and Apo E are the necessary apoproteins for the release and uptake of lipoproteins into cells, are critical to cholesterol transport, and help maintain cholesterol homeostasis.

Step-by-step explanation:

The two apoproteins needed for the release of lipoproteins and their uptake into respective cells, which are never interchanged with other lipoproteins, are Apo B-100 and Apo E. Apo B-100 is a critical component of Low-Density Lipoproteins (LDL), often referred to as "bad cholesterol", and plays a role in transporting cholesterol to cells.

Apo E, on the other hand, is recognized by receptor sites on the liver cells and helps to remove chylomicrons and Very-Low-Density Lipoproteins (VLDL) from the bloodstream. Both are integral to maintaining healthy cholesterol levels and preventing conditions such as atherosclerosis.