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Compare LCAT and ACAT in terms of location and substrates.

a) LCAT: Extracellular, cholesterol; ACAT: Intracellular, triglycerides
b) LCAT: Intracellular, triglycerides; ACAT: Extracellular, cholesterol
c) LCAT: Extracellular, triglycerides; ACAT: Intracellular, cholesterol
d) LCAT: Intracellular, cholesterol; ACAT: Extracellular, triglycerides

User Riffraff
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Final answer:

LCAT is extracellular and works with triglycerides, while ACAT is intracellular and works with cholesterol.

Step-by-step explanation:

The correct answer is:

d) LCAT: Extracellular, triglycerides; ACAT: Intracellular, cholesterol

LCAT, or Lecithin-Cholesterol Acyltransferase, is an extracellular enzyme that plays a role in cholesterol metabolism. It converts cholesterol into cholesteryl esters by transferring a fatty acid from phosphatidylcholine to cholesterol.

ACAT, or Acyl-CoA Cholesterol Acyltransferase, is an intracellular enzyme that is responsible for esterifying cholesterol to form cholesteryl esters. It is primarily found in the endoplasmic reticulum of cells.

User Igor Bukanov
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