There are 24 choices for each letter (excluding i and o) and 10 choices for each digit, making a total of 24 * 10^4 * 24 = 4840000 possible license plates.
Letters: Excluding i and o, there are 24 possible choices for each letter (A-Z excluding both i and o).
Digits: There are 10 possible choices for each of the four digits (0-9).
Total combinations: Multiplying the possible choices for each element, we get the total number of license plates: 24 choices for the first letter * 10 choices for the first digit * 10 choices for the second digit * 10 choices for the third digit * 10 choices for the fourth digit * 24 choices for the second letter. This simplifies to 24 * 10^4 * 24 = 4840000.
Therefore, due to the possible confusion with i and o, there are 4,840,000 different license plates possible with one letter at the beginning, four digits in the middle, and another letter at the end.