Final answer:
At the Battle of Little Bighorn, Lieutenant Colonel George Custer and his men suffered a severe defeat at the hands of nearly 3,000 combined warriors of the Lakota, Cheyenne, and Arapaho tribes, led by Sitting Bull.
Step-by-step explanation:
The Battle of Little Bighorn
On June 25, 1876, the Battle of Little Bighorn occurred, marking a significant event in United States history. Lieutenant Colonel George Custer led the U.S. Army's Seventh Cavalry in an attack against what he believed to be a small Native American encampment by the Little Bighorn River. However, Custer vastly underestimated the number of Plains warriors he would face. The encampment was composed of Lakota, Cheyenne, and Arapaho warriors—a collective force of nearly 3,000, united by the Lakota Sioux spiritual leader Sitting Bull.
Custer's forces were attempting a surprise attack but instead found themselves surrounded by the significantly larger Native American force. Custer and his 262 men and support units were quickly overwhelmed in the bloody confrontation, experiencing devastating losses in what became known as Custer's Last Stand. The aftermath of the battle saw Native American tribes such as the Lakota and Sioux flee or return to tribal life as the U.S. Army escalated its efforts to remove them from their lands.
In this engagement, none of the options suggesting involvement by General Ulysses S. Grant or General Robert E. Lee are accurate. The correct option regarding what happened at the Battle of Little Bighorn is that Lieutenant Colonel George Custer's troops were overwhelmed by a force of 2,000 indigenous Plains warriors.