Question

Using ncbi, look at the alternatively spliced transcripts for human smndc1. translation starts at the same nucleotide for both splice variant

O True
O False

Answer 1

In the case of the SMNDC1 gene, alternative splicing could result in transcripts where translation starts at the same nucleotide if the exon including the start codon is not altered.

Step-by-step explanation:

The question pertains to the human SMNDC1 gene and its alternatively spliced transcripts. In this context, translation refers to the synthesis of proteins from mRNA. Whether translation starts at the same nucleotide for both splice variants is contingent on the specific splicing event. If alternative splicing involves only the introns, and if the exons remain in their original order without losing or modifying the exons containing the start codon, then translation could indeed start at the same nucleotide.

However, depending on the composition of the two splice variants, it is also possible that translation could start at different nucleotides if, for instance, alternative splicing alters the exon containing the start codon. The existence of 5' UTR and 3' UTR regions is crucial, as they are elements of the mRNA that can be variably included in the transcripts, potentially leading to mRNAs with differing stability.

Mutations, including transversion mutations, in areas such as introns may lead to new splicing patterns, contributing to the diversity of the spliced mRNA and functional protein isoforms. Similarly, different spliceosome recognition sites may contribute to this complexity. Overall, alternative splicing is a mechanism for gene regulation that can create diverse protein products from a single gene.