Final answer:
In eukaryotes, DNA packing affects gene expression primarily by increasing gene transcription.
Step-by-step explanation:
In eukaryotes, DNA packing affects gene expression primarily by increasing gene transcription. When DNA is tightly packed around histone proteins, it becomes less accessible to transcription factors and RNA polymerase, resulting in decreased gene expression. Conversely, when DNA is loosely packed, transcription factors and RNA polymerase can more easily bind to the DNA, leading to increased gene transcription and ultimately enhanced protein synthesis.