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What are the precursors to cholesterol, starting with acetyl coA?

User Dean Sha
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Final answer:

The production of cholesterol starts with acetyl CoA and requires several intermediates like HMG CoA and mevalonate, ultimately leading to cholesterol, a crucial component of cell membranes.

Step-by-step explanation:

The synthesis of cholesterol commences with acetyl CoA and involves numerous steps to produce various intermediate compounds before reaching the final product, cholesterol. Initially, acetyl CoA is converted into hydroxymethylglutaryl CoA (HMG CoA) through an enzymatic reaction involving HMG-CoA synthetase.

HMG CoA is a key precursor in cholesterol synthesis and also an intermediate leading to the production of ß-hydroxybutyrate, a primary ketone body. The process continues as HMG CoA undergoes a reduction by HMG-CoA reductase, a rate-limiting step, to give rise to mevalonate.

Further progression through the pathway involves the formation of isoprene units, squalene, and ultimately, cholesterol. The pivotal importance of this pathway lies in its production of cholesterol, a fundamental component of cell membranes and a precursor for steroid hormone synthesis.

User Thomas E
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