Final answer:
The quantity of DNA in a cell doubles during the S phase of interphase.
Step-by-step explanation:
The quantity of DNA in a cell doubles during the S phase of interphase. During interphase, which is the longest phase of the cell cycle, the cell undergoes three distinct periods: G1, S, and G2. The S phase is when the cell replicates its DNA, resulting in the doubling of the amount of DNA in the cell.