Final answer:
The presence of CCleaner might indicate anti-forensic activities, as it is used to remove traces of computer activity that could be used in forensic investigations.
Step-by-step explanation:
The presence of a program like CCleaner might indicate anti-forensic activities. CCleaner is a utility program that cleans potentially unwanted files and invalid Windows Registry entries from a computer. In the context of digital forensics, it is significant because it can be used to clean traces of user activity as well as system logs which might otherwise be used in an investigation. Given that, its presence could be a sign that someone was attempting to remove evidence of their activities on a computer. It does not directly relate to full disk encryption, malware packing, or MAC time modifications, which are different forensic concerns.