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Many granulosa cells release a lot of ___________ eventually resulting in ______ surge

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Final answer:

Many granulosa cells release a significant amount of estrogen, leading to the LH surge, resulting in ovulation.

Step-by-step explanation:

This is about the events that occur in the ovarian cycle, particularly in the context of hormone secretion and ovulation. Many granulosa cells release large amounts of estrogen, which eventually leads to a LH surge. This surge of luteinizing hormone stimulates a chain of events that includes the resumption of meiosis in the dominant follicle, proteolytic activities leading to the breakdown of the ovarian wall, and the final release of the oocyte, a process known as ovulation.

Following ovulation, the remaining granulosa cells undergo luteinization, transforming the collapsed follicle into the corpus luteum, which then begins to secrete progesterone. This progesterone is essential for the establishment and maintenance of pregnancy and also exercises negative feedback on the hypothalamus and pituitary, preventing the development of new dominant follicles.

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