Final answer:
The major question was whether Saddam Hussein still possessed weapons of mass destruction, as this suspicion was used by the Bush administration as a primary justification for the invasion of Iraq in 2003.
Step-by-step explanation:
The major question concerning the invasion of Iraq in 2003 was not whether Saddam Hussein had nuclear weapons, but rather if he possessed weapons of mass destruction (WMDs) in any form, which could include chemical, biological, or nuclear weapons. Despite Saddam Hussein's history of using WMDs against enemies and reports that he had expelled UN weapons inspectors in 1998, there was much debate and conflict of intelligence regarding the actual threat he posed. United Nations Special Commission and International Atomic Energy Agency inspectors, as well as the head of the United Nations Monitoring, Verification and Inspection Commission, found no evidence of current WMD stockpiles, yet the Bush administration chose to prioritize the potential threat of WMDs and Hussein's non-cooperation as justification for military action, culminating in Operation Iraqi Freedom.