Final answer:
European diseases brought to the New World wiped out a large percentage of the native population, leading to animosity towards the remaining Europeans.
Step-by-step explanation:
The native population was devastated by European diseases brought to the New World, such as smallpox, influenza, measles, and typhus. While Europeans had developed some resistance to these diseases, Native Americans had no immunity. As a result, disease wiped out a large percentage of the native population, which led to animosity and hostility towards the remaining Europeans.