Final answer:
To maximize iontophoresis penetration depth, the area should be heated before application to increase skin permeability, allowing for deeper penetration of ions.
Step-by-step explanation:
To maximize the depth of penetration with iontophoresis, it is generally advised to warm the area prior to application. Heating the area can help in increasing the permeability of the skin, making it easier for ions to penetrate. In contrast to protocols like ultrasound diathermy, which also rely on heat for deep tissue treatments, iontophoresis requires heat primarily for enhancing penetration of the ions. Therefore, the correct pre-application procedure would be to heat the area. Heating the skin before applying the iontophoresis treatment increases the blood flow and helps to widen the blood vessels, allowing for deeper penetration of the ions. This can be done by applying a warm compress or using a heating pad.