Question

The p53 tumor suppressor is activated and stabilized by ___ and ___ in response to DNA damage to arrest the cell cycle, but can also induce apoptosis

Answer 1

The p53 tumor suppressor protein is activated and stabilized by cellular stress or DNA damage to arrest the cell cycle and induce apoptosis if the damage cannot be repaired.

Step-by-step explanation:

The p53 tumor suppressor protein is activated and stabilized by cellular stress or DNA damage. It acts when the cell is undergoing preparatory processes during the G₁ phase of the cell cycle and detects damaged DNA. If the DNA can be repaired, p53 halts the cell cycle and recruits enzymes for DNA repair. However, if the damage cannot be repaired, p53 can induce apoptosis or cell death to prevent the duplication of damaged chromosomes.