Final answer:
PDMS is based on continuum mechanics and hydrodynamics, specifically in the overdamped limit, to model cell adhesion and migration. Approaches like hydrodynamic models, active gel theory, and level set models are used to describe these cellular processes.
Step-by-step explanation:
The theoretical framework behind PDMS (Polydimethylsiloxane) in the context of cell behavior, like cell adhesion and migration, is primarily based on the principles of continuum mechanics and hydrodynamics in the overdamped limit. This framework is appropriate due to the small Reynolds numbers characteristic of cellular flows. Within this realm, various models are applied, such as the hydrodynamic model for cell migration which includes factors like membrane tension and myosin contractility, and the active gel theory, which is an extension of hydrodynamics that focuses on polarized active gels. Other notable approaches include level set or phase field models and models that incorporate discrete elements like single focal adhesions and stress fibers to provide a comprehensive view of cell dynamics.
PDMS, also known as Polydimethylsiloxane, is based on hydrodynamics in the overdamped limit. It is a natural framework used to study the migration and shape changes of cells. PDMS models balance shear and compressive forces in viscoelastic fluids with forces arising from myosin contractility and flow over adhesion sites, considering membrane tension as a boundary condition.