Question

The BBB is more like oil than water, substances that are more oil soluble will be able to pass

through it more easily. Though heroin, morphine, and hydrocodone are very similar in their core
structure, heroin is ?
than morphine and oxycodone because it does not have OH groups with which to form ?.
This makes heroin more ? than morphine and oxycodone.
Because the blood-brain barrier is more like oil than water, heroin can cross it ? than morphine
and oxycodone.

Answer 1

The chemical properties of heroin make it more nonpolar than morphine and oxycodone, allowing it to more easily cross the blood-brain barrier.

Step-by-step explanation:

Heroin vs Morphine and Oxycodone

Heroin is less soluble in water and more similar to oil than morphine and oxycodone. This means that substances that are more oil soluble are able to pass through the blood-brain barrier (BBB) more easily.

Unlike morphine and oxycodone, heroin does not have hydroxyl (OH) groups with which to form hydrogen bonds. This makes heroin more nonpolar than morphine and oxycodone.

Because the BBB is more like oil than water, heroin is able to cross it more easily than morphine and oxycodone.