Final answer:
When determining likely threat COAs, several screening criteria are utilized to analyze threat COAs. These criteria include relevance, effectiveness, speed, robustness, and accuracy and reproducibility.
Step-by-step explanation:
When determining likely threat COAs, several screening criteria are utilized to analyze threat COAs. These criteria include relevance, effectiveness, speed, robustness, and accuracy and reproducibility.
Relevance: The screening process should have good concordance with the corresponding in vivo properties of the threat, requiring validation with standard compounds of known performance.
Effectiveness: The screening criteria should eliminate a substantial fraction of compounds without eliminating every compound to avoid unnecessary delays.
Speed: The experimental procedure must be fast enough to keep up with the input rate of new compounds from chemistry.
Robustness: The screening procedure must be applicable to a wide variety of chemical structures.
Accuracy and reproducibility: Any screening procedure has an inevitable characteristic error rate, but false negatives should be minimized to avoid eliminating potential threats from further testing.