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When determining likely threat COAs, what screening criteria do we utilize to analyze threat COAs?

User AllenG
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Final answer:

When determining likely threat COAs, several screening criteria are utilized to analyze threat COAs. These criteria include relevance, effectiveness, speed, robustness, and accuracy and reproducibility.

Step-by-step explanation:

When determining likely threat COAs, several screening criteria are utilized to analyze threat COAs. These criteria include relevance, effectiveness, speed, robustness, and accuracy and reproducibility.

Relevance: The screening process should have good concordance with the corresponding in vivo properties of the threat, requiring validation with standard compounds of known performance.

Effectiveness: The screening criteria should eliminate a substantial fraction of compounds without eliminating every compound to avoid unnecessary delays.

Speed: The experimental procedure must be fast enough to keep up with the input rate of new compounds from chemistry.

Robustness: The screening procedure must be applicable to a wide variety of chemical structures.

Accuracy and reproducibility: Any screening procedure has an inevitable characteristic error rate, but false negatives should be minimized to avoid eliminating potential threats from further testing.

User Shauntell
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