Final answer:
SSSS may appear to have positive Nikolsky sign but traditionally considered negative. Pemphigus vulgaris and TEN both show a positive Nikolsky sign while bullous impetigo has a negative Nikolsky sign.
Step-by-step explanation:
List of Conditions with Nikolsky Sign Status:
The Nikolsky sign is a clinical dermatological sign which is useful in diagnosing skin conditions with epidermal desquamation. A positive Nikolsky sign is when gentle pressure or friction on the skin causes exfoliation of the outermost layer whereas a negative Nikolsky sign does not lead to skin sloughing.
- Staphylococcal Scalded Skin Syndrome (SSSS): Negative Nikolsky sign - In SSSS, while the skin is tender, the Nikolsky sign may actually appear positive although traditionally defined as negative due to the level of skin cleavage.
- Pemphigus vulgaris: Positive Nikolsky sign - Pemphigus vulgaris is an autoimmune blistering disease that typically presents with a positive Nikolsky sign, indicating superficial epidermal splitting.
- Toxic Epidermal Necrolysis (TEN): Positive Nikolsky sign - TEN is a rare, life-threatening skin condition typically associated with a positive Nikolsky sign due to epidermal detachment.
- Bullous Impetigo: Negative Nikolsky sign - Bullous impetigo is usually caused by Staphylococcus aureus and while it results in bullae formation the Nikolsky sign is typically negative as the cleavage occurs deep within the epidermis.
This list provides a content loaded overview whether the following conditions have a positive or negative Nikolsky sign and can serve as a reference point for medical students and health professionals.