Final answer:
The spleen is located in the upper-left quadrant of the abdomen, causing pain from this organ to typically be felt in the left upper abdominopelvic quadrant.
Step-by-step explanation:
Pain originating from the spleen would most likely be felt in the left upper abdominopelvic quadrant. This is because the spleen is located in the upper-left quadrant of the abdomen, adjacent to the left kidney and just inferior to the diaphragm. When the spleen ruptures, a condition that can be recognized by Kehr's sign, blood spills into this region, leading to pressure on the diaphragm.
Since the diaphragm lies just above the spleen, it is the pressure on the diaphragm that gives rise to the pain sensation linked to the spleen, often resulting in referred pain that can be felt in the shoulder and neck areas as well.