Final answer:
The most appropriate antibiotic for a college student with symptoms suggesting bacterial rhinosinusitis is amoxicillin-clavulanate.
Step-by-step explanation:
The college student's symptoms point to a likely case of bacterial rhinosinusitis, which is characterized by nasal congestion, fever, cough, facial pain, and yellow-green nasal discharge persisting for more than a few weeks. The organism responsible for bacterial rhinosinusitis can often be Streptococcus pneumoniae, Haemophilus influenzae, or Moraxella catarrhalis, which are common following a viral upper respiratory infection. In such cases, first-line antibiotic therapy is typically amoxicillin-clavulanate, given its efficacy against these commonly implicated pathogens.