Final answer:
The role of religion has fluctuated historically, with it playing an insignificant role in politics and economy in some areas, such as those founded by Quakers, while in other areas like Calvinist communities, it had a profound influence.
Step-by-step explanation:
Throughout history, the role of religion has varied significantly in different societies and during different time periods. For instance, during the medieval period, religion and politics were deeply intertwined, with secular leaders often relying on connections to the Roman Catholic Church for legitimacy. However, in the context of the question, one might infer that religion played an insignificant role in certain regions or eras. In Pennsylvania, founded by Quakers, religion played a minor role in politics and economy due to the practice of religious tolerance. In contrast, Calvinist beliefs influenced the political, economic, and social lives of the colonists in other areas significantly. Meanwhile, in the United States, the level of religious influence varies, with some areas becoming more secular and others experiencing a rise in fundamentalism.