Final answer:
The epicenter of pan-Indian resistance leading to the Northwest Indian War was the Ohio Valley, where the Western Confederacy formed to oppose American settlement. Key leaders like Joseph Brant, Little Turtle, and the Shawnee brothers played vital roles. The conflict raised important issues of Native sovereignty and was concluded by the Treaty of Greenville in 1795.
Step-by-step explanation:
The epicenter of the pan-Indian resistance that led to the Northwest-Indian War from 1791-1795 was the territory known broadly as the Northwest, encompassing parts of the Ohio Valley. The Western Confederacy, applied with arms by British agents, stood firmly against American advancement into these lands.
The Confederacy was formed as a response to American settlers who increasingly encroached on Native American lands following the Revolutionary War. This allegiance of native tribes, including the Shawnee, Miami, and Lenape, formed with the help of Mohawk leader Joseph Brant and other influential leaders such as Miami chief Little Turtle and the Shawnee brothers Tenskwatawa and Tecumseh.
The war signaled a pivotal testing ground for the new American republic, especially in its handling of Native American relations and federal power. The Treaty of Greenville in 1795 concluded the conflict, with significant land cessions in Ohio and parts of modern-day Indiana, including important future city sites. However, despite promises for a "lasting boundary," further settler incursion ensued, reflecting the ongoing challenge of honoring treaties and the sovereignty of Native Americans during the period of expansion.