Final answer:
Abnormalities in chromosome number, caused by nondisjunction, can lead to an irregular number of homologous chromosomes. This mutation occurs frequently in humans and can result in disorders like Down syndrome.
Step-by-step explanation:
Abnormalities in chromosome number, such as the loss or gain of chromosomes, can result in an irregular number of homologous chromosomes and are caused by a process called nondisjunction. Nondisjunction occurs when homologous chromosomes or sister chromatids fail to separate properly during meiosis.
This type of mutation can occur in various organisms, but it is most common in humans. Disorders like Down syndrome, which is caused by an extra copy of chromosome 21, are examples of chromosome number disorders that occur frequently in humans.