Final answer:
Osteoclasts begin resorption in response to heavy force as part of bone remodeling, stimulated by hormones like parathyroid hormone, and work concurrently with osteoblasts in maintaining bone health.
Step-by-step explanation:
Osteoclasts in the bone marrow begin resorption during heavy force, which is a natural response to increased stress on the bones.
The process of bone resorption by osteoclasts is a crucial part of bone remodeling, a dynamic activity where bone is continuously being broken down and reformed. These multinucleated cells originate from white blood cells such as monocytes and macrophages. The resorption activity involves the digestion of bone matrix proteins using lysosomal enzymes at an acidic pH level facilitated by carbonic anhydrase II. Parathyroid hormone (PTH), thyroid hormones, and other factors can stimulate osteoclasts to increase their bone-resorbing activity.
As osteoclasts break down bone tissue, the released minerals like calcium and phosphorus are then transferred into blood capillaries, helping to maintain mineral homeostasis in the blood. Simultaneously, osteoblasts are active in bone formation to maintain the balance necessary for healthy bone structure.