Final answer:
The file that contains user-specific registry settings in a profile is the Ntuser.dat file. It contains the personal settings and preferences for a user's profile in the Windows operating system.
Step-by-step explanation:
The file in a profile that contains user-specific registry settings is Ntuser.dat. This file is part of the Windows operating system and is created for each user. When a user logs in, the system loads the Ntuser.dat file, which contains personal settings and preferences. It acts similarly to a user's personalized set of instructions for the operating system. The Ntuser.dat file can be contrasted with AppData, which contains user-specific data for applications, and Local Settings, which includes temporary files and settings. Files like Ntuser.man are mandatory user profiles that are read-only, and System.dat is not a user-specific file but rather a part of the Windows registry system files.