Final answer:
George Washington's presidency focused on two foreign policy principles: neutrality to avoid entangling alliances which could lead into international disputes, and promoting friendly trade relations with all nations without forming political alliances that might compromise U.S. interests.
Step-by-step explanation:
Two key principles of U.S. foreign policy during George Washington's presidency were non-interventionism and the promotion of trade without political alliances. First, Washington emphasized neutrality and warned against entangling alliances, particularly with the European powers involved in ongoing conflicts. He believed that the young nation should avoid being drawn into international disputes that were not in its direct interest. Second, Washington endorsed the principle of establishing friendly trade relations with all nations. He saw economic interactions as beneficial but was cautious about political alliances that might compromise the nation's independence and drag it into unnecessary wars.