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Serological testing on a potential cadaver donor reveals a reactive anti-HIV2 antibody screening test. The screening test is positive on repeat testing, but the confirmatory test is negative. What happens to the tissue?

a. May be used; confirmatory test is negative
b. May be used; HIV antibody is not a required test
c. May not be used; discrepant results obtained
d. May not be used; results of confirmatory test can't override multiple positive screening test.

User Iclman
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1 Answer

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Final answer:

The tissue from the cadaver donor may be used as the negative confirmatory test (like a Western blot or nucleic acid test) suggests that the initial positive antibody screening tests were likely false positives. Final decisions should adhere to current medical guidelines and involve consultation with healthcare experts.

Step-by-step explanation:

In the case where a potential cadaver donor has a reactive anti-HIV2 antibody screening test, which repeats positive but is followed by a negative confirmatory test, the resulting action is nuanced. The confirmatory test, such as a Western blot or nucleic acid test, is generally more specific and is used to rule out the possibility of false positives that might occur in the initial antibody screening due to cross-reactivity with other antigens. Therefore, if the confirmatory test is negative, it often means that the initial positive result was a false positive.

The tissue from the cadaver donor may still be considered for use, as the negative confirmatory test overrides the initial antibody screening tests. It is important to note that tissue donation and transplantation guidelines might vary by region and could be influenced by policy changes or updated medical understanding. Thus, the final decision should be based on current guidelines and in consultation with medical professionals and transplant experts.

User Benny Hallett
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