Final answer:
Combining alcohol with drugs like opiates and sedatives can lead to serious risks such as respiratory depression, coma, and death. Alcohol consumption on its own can also have negative effects and increase the risk of addiction and overdose. Seeking medical supervision is important when trying to overcome addiction to these substances.
Step-by-step explanation:
The dangers of combining alcohol with drugs like opiates and sedatives include additive CNS and respiratory depressant effects, which can lead to respiratory depression, coma, or even death. For example, barbiturates increase the binding affinity of benzodiazepines, exaggerating their effects. Alcohol consumption also has serious risks on its own, including sedation, coordination problems, and the potential for addiction and overdose. Combining alcohol with prescription opioids can increase the risk of side effects, addiction, and overdose. It's important to seek medical supervision when trying to overcome addiction to these substances.