Final answer:
During a cardiac arrest, administering negative inotropic agents such as beta blockers or calcium channel blockers may be detrimental as they reduce heart contractility. Potassium channel blockers like amiodarone and procainamide need to be used with caution due to their impact on cardiac electrical activity.
Step-by-step explanation:
In the context of a cardiac arrest, certain drugs may be detrimental to administer and can worsen the patient's condition. Negative inotropic agents, which decrease the strength of heart's contraction and stroke volume (SV), can be harmful during a cardiac arrest. Such agents include beta blockers like propranolol and calcium channel blockers like dihydropyridine, phenylalkylamine, and benzothiazepine. These drugs, usually helpful in treating conditions such as angina pectoris, can further impair the heart's ability to pump blood if given during a cardiac arrest. Additionally, potassium channel blockers like amiodarone and procainamide are used to correct abnormal heart rhythms but must be used cautiously as their action on voltage-gated K+ channels can affect the heart's electrical activity.