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The four cardinal signs of inflammation are:

-Flare, wheals, fever, cough
-Rash, pus, heat, rubor
-Heat, pain, vesicles, fever
-Redness, heat, swelling, pain

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Final answer:

Inflammation is the body's response to injury or infection, characterized by redness, swelling, pain, and local heat. The signs of inflammation were first recorded in ancient times and can be accompanied by loss of function.

Step-by-step explanation:

Inflammation is the body's response to injury or infection. It is characterized by four cardinal signs-redness, swelling, pain, and local heat. These signs were first recorded in ancient times by Cornelius Celsus during the Roman Empire. Inflammation can also be accompanied by a fifth sign, loss of function. The signs of inflammation are caused by increased blood flow to the affected area and the release of chemicals that attract immune cells to the site of injury or infection. Increased blood flow and immune cell recruitment are responsible for the signs of inflammation.

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